ABSTRACT
Acute respiratory distress syndrome (ARDS) can cause pulmonary vascular dysfunction, increase right ventricular afterload and lead to right ventricular failure,also known as acute cor pulmonale. Mechanical ventilation to maintain oxygenation and ventilation has a negative impact on right ventricular function,which may lead to lung-right ventricular interaction and aggravate the deterioration of right ventricu-lar failure,which may be one of the causes of right ventricular failure. Therefore,in the treatment of mechani-cal ventilation for ARDS,attention must be paid to the right ventricular function of patients.
ABSTRACT
Circular RNA(circRNA) is a class of endogenous non-coding RNA molecules,which is ubiquitous in eukaryotic cells.They have a closed ring structure,and are mainly composed of exons and / or introns.Circular RNAs have been widely studied in recent years,and studies show that they are remarkably stable,highly conserved and cell-or tissue-specifically expressed.Recently,it has been found that circRNAs can regulate gene expression at the transcriptional or post-transcriptional level by interacting with microRNAs and other molecules.Recent studies have shown that circular RNA may be associated with various diseases,including atherosclerotic vascular disease,prion diseases,neurological disorders,osteoarthritis and diabetes mellitus.In addition,circular RNAs exhibit abnormal expression in a variety of types of cancers,including colorectal cancer,hepatocellular carcinoma,and gastric cancer.Therefore,we believe that circular RNA can be used as a diagnostic marker or therapeutic target of clinical diseases.This article reviews the potential of circular RNA as a diagnostic marker and therapeutic target.
ABSTRACT
Objective To analyze the radiolngical findings of mediastinal ganglioneuroma and to improve its diagnostic accuracy. Methods Imaging data of 8 cases of pathologically proven mediastinal ganglioueuroma were restrospectively analyzed. Results These tumors could occur in the anterior mediastinum, middle mediastinum or posterior mediastinum, with a preference for the posterior mediastinum (6/8). No specific clinical symptoms and signs were observed. Well-defined enlargrment of mediastinum with homogeneous density was shown on plain X-Ray. CT scanning was performed in 7 cases, including non-contrast scan alone (n = 3 ), both non-coutrast and contrast-enhanced scans ( n = 4). Round or oval shaped, well circumscribed, homogeneous or slightly heterogeneous, hypadense masses were demonstrated on non-contrast scan. Spotty calification could be found in a few cases. Homogeneous or slightly heterogeneous enhancement was seen following the intravenous injection of contrast material. Large tumors showed a tendency of wedging into the space between adjacent organs and structures, and encasing the nearby large vessels. MR without contrast was performed in 1 case. T1 WI showed isointensity to adjacent muscle, T2WI showed homogeneous hyperintensity. Multi-planar reconstruction provided more information concerning the relationship of the mass lesions with neighboring structures. Conclusion Mediastinal ganglioneuromas have some specific characterstics on imaging studies, which could assist in pre-operative diagnosis and surgical planning.
ABSTRACT
Objective:To explore the diagnostic value of MRI in the diagnosis ofbone Eosinophilic GranulomaI. Methods:The clinical and imaging materials of 13 patients with eosinophilic granuloma of bone proved by histopathology were analyzed retrospectively.The imaging examination included plain films(n=13),CT(n=12),and MRI(n=13).Results:MR identified all lesions;With one exception,all lesions were hypointense on T1-Weighted images and hyperintense on T2-Weighted images;The lesions and associated soft tissue abnormalities were very conspicuous on short T1 inversion sequences and T1-Weighed post-contrast images;Follow-up MRI studies in two patients after chemotherapy showed decreased size and enhancement of lesions compared with the baseline studies.Three lesions were not identified on plain films.MRI showed greater abnormality than plain radiographs did.CT could identify all lesions also,and the main imaging findings included bone destruction,adjacent bone cortex involvement,periosteal reaction and sof t tissue mass or swelling. Conclusion:MRI can clearly demonstrate the extent of bone involved, the change of soft tissue and sequestrum.It can also acquire the anatomic and pathologicd details of bone and and soft tissue.But X-ray film and CT may improve the diagnostic and differential diagnostic accuracy.